Interrogating Congenital Heart Defects with Noninvasive Fetal Echocardiography in a Mouse Forward Genetic Screen Liu et al: Modeling Complex Congenital Heart Disease in Mice
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Interrogating congenital heart defects with noninvasive fetal echocardiography in a mouse forward genetic screen.
BACKGROUND Congenital heart disease (CHD) has a multifactorial pathogenesis, but a genetic contribution is indicated by heritability studies. To investigate the spectrum of CHD with a genetic pathogenesis, we conducted a forward genetic screen in inbred mice using fetal echocardiography to recover mutants with CHD. Mice are ideally suited for these studies given that they have the same four-cha...
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